Page 57 - FoodFocusThailand No.197 August 2022

STRATEGIC R&D
swine flu, or religious restrictions. Consequently, most manufacturers 3. Enhanced External Protection of the Skin As previously
opt for aquatic collagen extracted from both marine vertebrates and mentioned, the outermost layer of the epidermis, or the stratum corneum,
invertebrates. The amino acids from hydrolyzed collagen improve is like a wall of bricks linked together by cement. The skin cells are bricks,
collagen production, and the oral consumption of collagen-enriched while the fats act as cement, and ceramide makes up 50% of these fats.
foods or supplements yields a better result than topical usage. To choose If this layer is weakened or has less ceramide, the water content in the
an adequate collagen-infused supplement, consumers should consider skin can be easily lost, leading to dryness and a decline in skin elasticity.
3 key factors: the collagen type, the extraction method, and the collagen Healthy skin must have a high amount of ceramide, which can be acquired
molecule’s size. The industrial collagen hydrolyzation breaks down through oral consumption of ceramide-enriched foods. Ceramide can
collagen proteins of 300 kDa into polypeptides of 1,000-8,000 Da, which be absorbed into the bloodstream through the intestinal walls. Foods
will then be broken down by enzymes into smaller collagen peptides of containing natural ceramide, which is also known as phytoceramide, are
1,000 Da or less. The breaking down of molecules should be carried soybean, wheat germ, sesame, grape seed, peanut, sweet potato, and
out through the use of bio enzymes as they are easier to control and do brown rice. Alternatively, consumers may choose to take food
not generate byproducts. This will result in peptides with lesser molecular supplements with plant-based ceramide instead.
Skin is the largest organ of the body. Taking good care of it from the
weight, higher absorbability, and more stable structures of amino acids. inside of our body will result in a visible outcome, which is a way to
2. Collagenase Inhibition Collagenases, such as MMP-1 (Matrix ensure sustainable beauty. The beauty from within can be achieved
metalloproteinase-1 or fibroblast collagenase), MMP-8 (Neutrophil through healthy, younger-looking skin. Nutrition, therefore, is an important
collagenase), and MMP-13 (Collagenase-3), play a key role in tissue key. The addition of collagen to the skin through collagen-inducing
changes. More of these enzymes are produced in inflamed areas where ingredients, the inhibition of collagen-damaging enzymes, and the
MMPs will break the helical structures of collagens, especially those external protection of the outer skin layers via the consumption of
found in bone, cartilage, and skin, thus leading to skin flaccidity, wrinkles, ceramide are the methods that can ensure beautiful, healthy skin and
and dryness. Therefore, it is necessary to find a way to inhibit the glowing inner beauty.
reactions of collagen-damaging enzymes and improve collagen
synthesis. Several plant extracts are found to have inhibitory properties
against these enzymes, especially those from plants containing
polyphenols such as flavonoid, phenolic acid, and tannin. A study into More Information Service Info C010
16 plant extracts aimed at discovering the anti-collagenase enzymes
that can inhibit collagenase activity revealed that white tea has the เอกสารอ้างอิง / References
Tamsyn SA Thring et.al 2009 Anti-Collagenase, anti-elastase and anti-oxidant
highest inhibition activity at 87%, while green tea has 47%. The activities of extracts from 21 plants. BMC Complimentary and Alternative Medicine
anti-collagenase activity of rose tincture is 41%, and that of lavender is Article number 9:27 (2009)
Juliet M. Pullar et.al 2017 The roles of Vitamin C in Skin health. Nutrients 2017
31%. Many food supplements for cosmetic purposes are currently being Aug; 9(8):866
produced from these extracts, which are to be administered orally to Nicholas N. DePhillipo et.al 2018 Efficacy of Vitamin C Supplementation on Collagen
prevent collagenase activity. Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review.
Orthopedic Journal of Sports Medicine V.6(10) 2018

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