Page 78 - FoodFocusThailand No.212 NOVEMBER 2023

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- Identify the active substances with antiviral activity
against SAR-CoV-2 in fingerroot extract, their structural
formulas, and the minimum effective concentration of each
substance.
- Study the active mechanisms and determine acute and
chronic toxicity and optimum dosage in animal testing.
- Study the safety of fingerroot extract by determining its
optimum dosage and potential side effects.
- Verify the fingerroot extract’s safety and efficacy in
100 – 1,000 patients.
- Develop the formulas and evaluate their properties,
such as solubility, dispersion, and stability, before the
registration and production of products for further distribution.
effective technology that can test samples of synthetic
substances, crude extracts, and pure natural substances in EDCC in becoming Thailand’s active substance
different forms simultaneously in large quantities, was used to
determine the effects of herbal extracts and the community’s collection center
geographic indications (GI). The collected data supported the To serve as Thailand’s active substance collection center,
development of the ecosystem and agricultural system called the ECDD, dedicated to the search for bioactive substances,
Smart Farming and improved the sustainability, safety, and has built a warehouse with a capacity of more than 100,000
standards of herbal wisdom-based products. The ECDD has active substances for natural substances, synthetic extracts,
initiated projects to enhance extraction potential and develop and crude extracts. In addition to extending its research
bioanalytical techniques. Additionally, to maximize Thai herbs’ collaboration with government organizations and the private
production potential and market value, the ECDD has sector to gather bioactive substances in Thailand, the ECDD
collaborated with numerous organizations throughout the public has established a chemical research unit to enhance the
and private sectors. potential in crude extract extraction and pure natural
The ECDD aims to produce raw extracts and pure substance separation. More than 6,000 substances are
substances from Thai herbs to increase their value and promote already available for testing, and the ECDD plans to increase
their acceptance worldwide, in which conducting in vitro tests the warehouse capacity to 10,000 substances within 1-2
and jointly developing formulas are the first steps in turning years.
them into herbal products. The ECDD has developed analytical
methods to enhance the performance of bioactivity tests by
developing cell-based assay platforms, biochemical assay More Information Service Info C013
platforms, and bacterial assay platforms, expanding
cooperation in animal testing and clinical trials, and working
with in vitro studies. These efforts are in addition to developing ข้้อมููลเพิ่่�มูเติ่มู / Additional Information
the extraction methods of natural active substances and ศููนย์์ความเป็็นเลิิศูด้้านการค้นหาตััวย์า จััด้ตัั�งขึ้้�นโด้ย์ความร่วมมือขึ้อง
expanding research cooperation to collect compounds with ศููนย์์ความเป็็นเลิิศูด้้านวิทย์าศูาสตัร์ (TCELS) คณะแพทย์ศูาสตัร์
bioactivities. โรงพย์าบาลิรามาธิิบด้ี แลิะคณะวิทย์าศูาสตัร์ มหาวิทย์าลิัย์มหิด้ลิ
เพื�อด้ำาเนินงานวิจััย์แลิะพัฒนาเทคโนโลิย์ีที�ใช้้ในการค้นหาสารป็ระกอบที�มี
Study of bioactive substances of Fingerroot คุณสมบัตัิทางช้ีวภาพแลิะสามารถพัฒนาเป็็นสารเริ�มตั้นในการพัฒนาเป็็น
(Boesenbergia rotunda (L.) Mansf.) against ผลิิตัภัณฑ์์เครื�องสำาอาง ผลิิตัภัณฑ์์เสริมอาหาร ผลิิตัภัณฑ์์จัากสมุนไพร
pathogens ตัลิอด้จันการพัฒนาเพื�อขึ้้�นทะเบีย์นย์าใหม่ในอนาคตั นอกจัากนี�
The ECDD, as a part of the research team, has previously ทางศููนย์์ EDCC สามารถให้บริการทางด้้านการสกัด้สารเพื�อการทด้สอบ
studied and investigated a variety of herbs, including fingerroot ความเป็็นพิษตั่อเซลิลิ์ การทด้สอบฤทธิิ�ทางช้ีวภาพ การทด้สอบการป็นเป็้�อน
extract. The findings indicated that the active substances เช้ื�อไมโครพลิาสมา แลิะย์ังให้บริการห้องป็ฏิิบัตัิการเพาะเลิี�ย์งเซลิลิ์
present in fingerroot extract are pinostrobin and panduratin A. พร้อมเครื�องมือแลิะวิเคราะห์ผลิอีกด้้วย์
These substances show antiviral activity against COVID-19, The ECDD was established in collaboration with the Thailand Center
according to in vitro experiments. In addition, Thai fingerroot of Excellence for Life Sciences (TCELS), Faculty of Medicine
extract shows antibacterial activity against Helicobacter pylori, Ramathibodi Hospital, and Faculty of Science, Mahidol University,
a risk factor for stomach cancer, according to an in vitro to conduct research and develop technology used in finding
bioactivity test. To better understand the bioactivities of Thai bioactive substances that can be used as materials for the
production of cosmetic products, dietary supplements, herbal
herbs, the ECDD intends to develop the fingerroot extract in products, as well as the registration of new drugs in the future.
the future, including pure natural ingredients and crude extracts. The EDCC also offers substance extraction services for cytotoxicity,
The research and development process of fingerroot extract bioactivity, and mycoplasma contamination tests and laboratory
before marketing is as follows. services with equipment for cell culture and analysis.
- Select fingerroot and grind it into a smaller size, then เอกสารอ้างอ่ง / Reference
extract ground fingerroot with 95% ethanol before drying the https://www.foodnetworksolution.com /nutraceutical-โภช้นเภสัช้
extract to obtain fingerroot powder.

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