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STRATEGIC R&D
SPECIAL FOCUS

Grapes have been praised since ancient times
for their beneficial health effects. Grape seed เอกสารอ้างอิง/References
(1) Effective separation of potent anti-proliferation and anti-adhesion
polyphenols are implicated in the so-called French components from wild blueberry (Vacinium angustifolium Ait.) fruits.
Paradox, a term referring to the observation that Mary Ann Lila et al., J. Agric Food Chem, 2004, 52, 6433-6442
(2) Effect of intake of resveratrol, resveratrol phosphate, and catechin-rich
cardiovascular disease is significantly lower in grape seed extract on markers of oxidative stress and gene expression
France than in many (northern) European countries in adult obese subjects. D. De Groote et al., Ann Nutr Metab, 2012, 61,
notwithstanding dietary fat intake is similar. 15-24, DOI: 10.1159/000338634
Grape polyphenols exert cardioprotective effect in pre- and postmeno
(3)
pausal women by lowering plasma lipids and reducing oxidative
Seeds from different geographic origins can be used for stress. Zern et al., J. Nutr., 2005, 135(8), 1911-1917
preparing grape seed extracts but one of the top quality products (4) Effect of GSE & Quercetin on cardiovascular & endothelial parameters
using selected seeds can be obtained from the Champaign region, in high-risk subjects. P.M. Clifton, J. Biomedicine & Biotechnology,
France. 2004(5), 272-278
By carefully selecting extraction and purification processes a (5) Effects of GSE beverage on blood pressure and metabolic indices in
range of products are made ranging from extracts rich in monomers dividuals with pre-hypertension: a randomized , double-blind, 2-arm,
parallel, placebo-controlled trial. E. Park et al., Br. J. Nutr., 2016, 115(2),
and dimers to products high in polymeric materials or intermediate 226-238, DOI: 10.1017/S0007114515004328
grades mimicking the natural polyphenol abundance in the seeds. (6) Examining the impact of grape consumption on brain metabolism and
Depending on literature cited, lower molecular weight fractions cognitive function in patients with mild decline in cognition:
are to be preferred due to their higher bio-availability, while other a double-blinded placebo controlled pilot study. J. Lee et al., Exp.
references clearly demonstrate that higher molecular weight Gerontology, 2017, 87(Pt A), 121-128, DOI: 10.1016/j.exger.2016.10.004
oligomers also exhibit high biological activity apparently not related
to bio-availability . Regardless of the above Kosher certified ข้อมูลเพิ่มเติม/Additional Information
(1)
a
Grape seed extracts offered by Ajinomoto OmniChem
materials, compatible with vegetarian diets, that are produced under
a FSSC-22000 certified food safety management system can now
be offered to the market as well.
Grape seed extracts are very strong (poly)phenolic anti-
a
oxidants that can be used alone or combined with other anti-
oxidants, e.g. vitamin C or E in for instance functional beverage
formulations. These effects are not only observed
in-vitro, but also positively influence markers of
oxidative stress in-vivo and expression of
genes coding for important human anti-
oxidant enzymes .
(2)
Studies indicate that grape seed
extracts positively influence blood
plasma lipids (3) , reduce platelet
aggregation and positively influence
(2)
vascular function . Furthermore it has been
(4)
shown that grape seed polyphenols can lower
arterial blood pressure . All these effects are
(5)
associated with a healthy lifestyle and help to sustain good
cardiovascular health.
Additionally emerging evidence suggests that grape seed
extracts could also help to maintain cognitive function . Whether
(6)
this effect is related to improved blood flow to the brain or to other
mechanisms is subject to further research.

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