Page 43 - FoodFocusThailand No.169 April 2020

STRATEGIC R & DD
STRATEGIC R &

Proteoglycan is a notable biological production in the skin, การเด่น การข้ึ้น-ลงบันได
component in both joint and skin the improvement from
following on from collagen and skin sagging, the
improvement of skin
hyaluronic acid. Proteoglycans are elasticity, moisturizing
glycoproteins contained in skin and effect, and wrinkle
cartilage in large amounts. The recovery, etc.
history of the unique proteoglycan
รูปที� 2 ค่าวััดระดับควัามเจ็บป็วัด (VAS)
production started from the local Figure 2 Result of Visual Analogue Scale
cuisine of Northern Japan (e.g.
Hokkaido, Aomori) named “Hizu ข้้อมููลเพิ่่�มูเติ่มู/Additional Information
1
VAS (Visual Analogue Scale) เป็็นการวััดควัามป็วัดโดยใช้้สเกลเส้นตรงยาวั 100 มม.ป็ลายด้านหน่�งแทนค่าด้วัย 0
Namasu” which is mixed of thinly- หมายถึ่ง ไม่ป็วัดป็ลายอีีกข้้างหน่�งงแทนค่าด้วัย 100 หมายถึ่ง ป็วัดรุนแรงมากที�สุด
sliced salmon head cartilage and VAS (visual analogue scale) is a common pain scale. Using a 100 mm scale, test subjects show the degree
of current pain with no symptoms as 0 and the severest pain ever experienced as 100.
daikon seasoned with vinegar gave a เอกสารอ้างอ่ง/References
hint to develop the unique production Teruaki Masutani et al., The Japanese Society for Bone and Mineral Research Twenty-eight Lecture, 268 (2010)
method. This might be one of their Tatsuji Takahashi et al., Japan Society of Nutrition and Food Science Sixty-fifth lecture, 250 (2011)
secret to having youthful and healthy
life. Raw ingredients reliably traced,
Hokkaido and Aomori region since it
is an abundant natural source.
On the skin proteoglycan promote epidermal
cell growth, collagen production, hyaluronic acid
production, increase moisture and skin elasticity.
For cartilage/joint, they promote cartilage
health and reduce joint pain as well. Cartilage is
mostly consists of cartilage matrix such as water,
collagen, and proteoglycan. Proteoglycan is
considered as an especially important component
because it is responsible for cartilage’s unique
functions such as elasticity and shock-resistance.
Activity to Promote Cartilage
Differentiation
Proteoglycan’s activity to promote cartilage
differentiation was examined using in vitro
cartilage multi-step differentiation model with
ATDC5 cells. In this experiment, different
concentrations of proteoglycans (12.5, 25 and 50
µg/ml respectively) were analyzed. As a result, a
concentration-dependent activity to promote
differentiation was observed (Figure 1).
Proteoglycan is expected to accelerate the
regeneration of cartilage, prevent osteoarthritis,
and reduce its symptoms.
Reduction of Joint Pain
(Clinical Test)
Twelve Japanese male and female test subjects
in their forties to seventies (average age 58.8)
with mild knee joint pain who submitted their
written consent ingested proteoglycan (50 mg/
day) for twelve weeks. Then, the pain reduction
effect was evaluated using the VAS method. Oral
1
consumption of proteoglycan significantly reduce
the pain during walking and going up and down
stairs starting at the second week of ingestion.
Proteoglycan is expected to have an effect to
reduce joint pain (Figure 2). Oral consumption of
proteoglycan is one possible safe way to relieving
knee pain. With a small daily dosage (50 mg/day)
improves overall joint support.
Proteoglycan functionalities for joint health
include the reduction of joint pain (clinical test)
and the promotion of cartilage health, etc.
Meanwhile, it also gives some benefit to the skin
health and beauty ; for example, the promotion
of epidermal cell growth factor (EGF) in the skin,
the promotion effect on hyaluronic acid production
in the skin, the promotion effect on Type I collagen APR 2020 FOOD FOCUS THAILAND 43