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STRATEGIC R &
STRATEGIC R & DD

Antioxidant

from Grape Seed

Grape Seed Extract is a highly standardized procyanidin
a
extract, obtained from white grape seeds harvested
exclusively in France, in Champagne area. It contains
monomers of catechin and epicatechin, procyanidin
dimers, trimers and polymers identified and controlled
by HPLC test method.

Procyanidins profile in Grape Seed Extracta OPC40
Total polyphenols: > 95%
Oligomeric Procyanidins (OPC):
≥ 40% for Grape Seed Extract OPC40
a
≥ 30% for Grape Seed Extract OPC30
a
Oligomeric procyanidins, more commonly known as OPC,
are phenolic compounds which are available in fruits, vegetables,
nuts. They can be found in grapes and more abundantly in seeds.
OPC are composed of a variable number of flavan units of
momomers catechin and epicatechin. The simplest procyanidins
are dimers, however trimers, tetramers and oligomers up to 10
units may be present in the procyanidin mixture of the grapes.
Benefits
Procyanidins have been reported to exhibit strong antioxidative
and free radical scavenging activities. Free radical production
occurs continuously in all cells as part of normal cellular function,
but in excess free radical production might play a role in many
diseases .
[1]
Oligomeric procyanidins (OPC) from grape seeds have been
shown to be a stronger free radical scavenger, inhibitor of tissue ข้อมูลเพิ่มเติม/Additional Information
oxidation and DNA damage than ß-carotene, vitamin C and a ExGrape Seed ผลิตภัณฑ์สารสกัดจากเมล็ดองุ่นขาวที่ผลิตโดยบริษัท GRAP’SUD
®
vitamin E . Specific antioxidant properties of Grape Seed Extract a ประเทศฝรั่งเศส
[2]
have been tested in vitro and in animal studies in collaboration ExGrape Seed Grape Seed Extract manufactured by GRAP’SUD, France
®
with the Medical School and the Nutrition Department of the b Pycnogenol สารสกัดเปลือกสนมาริไทม์จากประเทศฝรั่งเศส
®
University of Montpellier, in France. Grape Seed Extract has a Pycnogenol French Maritime Pine Bark Extract
a
®
high ORAC value TE per g and can inhibit the production of
superoxide anions in vitro on cells . เอกสารอ้างอิง/References
[3]
Oxygen Radical Absorbance Capacity (ORAC) is a method [1] Young, I.S. and J.V. Woodside, Antioxidants in health and disease. J Clin Pathol, 2001.
of measuring antioxidant capacities in biological samples in vitro. 54(3): p. 176-86.
Bagchi, D., et al., Cellular protection with proanthocyanidins derived from grape seeds.
[2]
Grape Seed Extract has a ORAC value superior to 15,000 μmol Ann N Y Acad Sci, 2002. 957: p. 260-70.
a
TE per g. [3] Shafiee, M., et al., Grape and grape seed extract capacities at protecting LDL against
Other results suggest that the intake of OPC increases the oxidation generated by Cu , AAPH or SIN-1 and at decreasing superoxide THP-1 cell
2+
resistance of blood plasma against induced oxidative stress in production. A comparison to other extracts or compounds. Free Radic Res, 2003.
rats , and in humans after test meal rich in oxidized and oxidizable 37(5): p. 573-84.
[4]
lipids . Intake of OPC may also play role in the prevention of [4] Koga, T., et al., Increase of antioxidative potential of rat plasma by oral administration
[5]
oxidative damages induced by UV in the skin. Studies on OPC of proanthocyanidin-rich extract from grape seeds. J Agric Food Chem, 1999. 47(5):
from grape seeds showed interesting effects on the inhibition of p. 1892-7.
[5]
Natella, F., et al., Grape seed proanthocyanidins prevent plasma postprandial oxidative
UV-induced melanogenesis on human melanocytes and on stress in humans. J Agric Food Chem, 2002. 50(26): p. 7720-5.
[6]
inhibition of the release of reactive oxygen species by epidermal [6] Zi, S.X., et al., Oligomeric proanthocyanidins from grape seeds effectively inhibit ultra
cells after UVB-induced stress in mices . Dietary supplement (4 violet-induced melanogenesis of human melanocytes in vitro. Int J Mol Med, 2009.
[7]
weeks) and topical formulations containing OPC from grape seeds 23(2): p. 197-204.
reduced erythema and increased skin hydration in humans after [7] Sharma, S.D., S.M. Meeran, and S.K. Katiyar, Dietary grape seed proanthocyanidins
UV irradiation . inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases
[8]
and nuclear factor-kappaB signaling in in vivo SKH-1 hairless mice. Mol Cancer Ther,
These results are promising about the benefit of OPC from 2007. 6(3): p. 995-1005.
grape seeds on the prevention of oxidative stress due to [8] Hughes-Formella, B., O. Wunderlich, and R. Williams, Anti-inflammatory and skin-hy
environmental and internal stress, especially on the skin which drating properties of a dietary supplement and topical formulations containing
acts as an effective barrier against the deleterious effects of solar oligomeric proanthocyanidins. Skin Pharmacol Physiol, 2007. 20(1): p. 43-9.
ultraviolet radiation.
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